Prof. Dr. Ferenc Krausz: Light pulses in medicine

Ultrashort laser pulses hold an enormous potential for investigating microscopic processes, which has far-reaching im­­pacts on natural sciences and fu­­ture technolo­gies. They open up new perspectives for modern medicine.

Light is the tool of the 21st century. In medicine, already today surgeons use so­­­phisticated laser systems to make pre­­cise cuts in deep layers of tissue, on­­co­l­­ogists detect cancer cells and ophthalmologists correct eye defects. In chemistry, scientists use light to ex­­plore the properties of protein structures at the atomic scale and in physics, light is the key to research into quantum phenomena in the microcosm.
At the Max Planck Institute of Quantum Optics (MPQ) in Garching and at Lud­wig-­Maximilians University in Munich (LMU), a team of about 100 scientists of the MPQ-LMU Laboratory for Attosecond and High-Field Physics (LAP) have specialized in the generation and application of ultrashort light pulses. Currently “ultra­short” refers to a pulse duration of less than 100 attoseconds. An attosecond is one billionth part of one billionth part of a second. It is the time that it takes light (which trav­­els at 300,000 kilometres per second) to cover the tiny distance cor­­re­­sponding to the diameter of three hydrogen atoms.
Attosecond light flashes are the shortest processes that humans can control today. They are located in the extreme ultraviolet spectrum of the light. By us­­ing attosecond light flashes, researchers gain insights into the movement of electrons in atoms, molecules and sol­­id materials. Electrons play a key role in almost all biological and chemical proc­­esses, but they are also indispensable in electronics. Attosecond light flashes are the only means to visualize electron behaviour on an atomic scale, that is, in the order of tenths of nanometres. The findings about fundamental process­es of nature obtained through these ex­­periments can, among other things, be used to better understand the microscopic causes of diseases, to identify effective treatments or to de­­velop new substances. In addition, at­­tosecond me­­­trology will also play a cen­­tral part in approaching the ultimate limit of speed in modern electronics.

The key to generating these light flashes and measuring time on an attosecond time scale are the forces that the electro­­magnetic field of visible and near-­­in­­fra­­red laser pulses exerts on elec­­trons. With the help of the Nobel Prize winning fre­­quency comb technique, developed by Professor Theodor Hänsch, LAP sci­­en­tists for the first time succeeded in “tam­­ing” these forc­­es by generating laser pulses with few, precisely controlled light waves. These laser pulses last only a few femtoseconds (one femtosecond = 1,000 attoseconds). For the first time, the electromagnetic force they exert on electrons can be precise­ly controlled on an attosecond time scale. Thus it enables the steering of electron motion in atom­­ic systems.

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If femtosecond pulses are combined with high energy, they can also be put to use in promising new applications in the area of medicine. If, for instance, the energy of light is concentrated in pulses of about ten femtoseconds’ du­­ration, the power of the latter will be well in excess of one terawatt. Even though the duration of such multi-terawatt femtosecond pulses is extremely short, they will deliver ten thousand times as much power as a modern nu­­clear power plant. The immense electric and magnetic forces which the light fields exert during this interval of time are capable of steering and controlling charged particles such as electrons, pro­­tons or ions. The forces of light are able to accelerate electrons almost to the speed of light. These high-energy elementary particles can then be used to produce X-rays. Since it was discovered by Wilhelm Conrad Röntgen in 1895, X-ra­­­diation has developed into a crucial aid in the field of life sciences and medicine. In spite of its enormous success, the cur­­rently used X-ray diagnostics reaches its limits when it comes to examining soft tissue particles, for ex­­ample, tumours in intact tissue.
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This gap might be closed in the still very young era of laser-driven X-ray generation. For the first time, ter­­a­­watt laser pulses are now used to create radiation. This tech­nique, which is presently be­­­ing de­­vel­­­oped at the MPQ-LMU Laboratory for Atto­­­second and High-Field Physics, will make it possible to obtain an entirely new quality of X-radiation by means of laser light. This is referred to as “brilliant ra­­di­ation”. It is achieved by bunching X-rays with a well-defined wavelength (to a beam that is mostly fo­­cused in one direction). As demon­strated by re­­­­­cent re­­search car­­ried out by scientists who work for the Munich Centre for Advanced Photonics (MAP) Cluster of Ex­­cel­lence, brilliant ra­­­di­­ation would enable medical doctors to identify even structures in the order of millimetres, such as tumours in the initial stage of development. In such tumours, the probability of metastasis is still very low. A local therapy, again using laser-generated proton or ion beams, will therefore significantly im­­prove the prospects for healing. Be­­sides an early diagnosis, the imaging process by means of brilliant X-rays is expected to substantially reduce the radiation dose for patients.
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Already today, brilliant X-radiation is pro­­duced in kilometre-size accelerator facilities. These existing facilities are expensive and not appropriate for everyday applications in medicine. Light-generated X-radiation might change that. The physical foundations for the laser-based generation of X-rays in com­­pact devices have been laid. Now it is time to transfer the results of basic re­­search to application-oriented projects. The newly designed Centre for Ad­­van­ced Laser Applications (CALA) is intended to put this idea into practice. The new research centre is to be built on the Garching Campus as part of the Munich Centre for Advanced Photonics Cluster of Excellence, and it is to be operated by scientists of the Munich-based universities Ludwig-Maximilians University and TU Munich.
CALA will accommodate a state-of-the-art short pulse laser. The primary pur­pose of this system is to advance biomedical imaging techniques with highly brilliant X-rays and to produce proton and carbon beams from compact, laser-driven sources for tumour therapy. The new laser-based systems that are de­­veloped by LAP team members are to combine the generation of brilliant X-ray and particle beams on a laboratory scale in the future. This will lead to significantly less costly application options, which will make the treatment method available to a much higher number of patients. CALA will strengthen the al­­ready outstanding and globally known location of Munich for laser sciences and optical technologies, and it will create challenging jobs for highly qualified people.

Ferenc_Krausz_public_keinThe author, born in Mór, Hungary, in 1962, has been a director at the Max Planck Institute of Quantum Optics since 2003 and is head of the division of Atto­­second and High-Field Physics. In 2004, he also took over the chair of Ex­­per­i­men­­tal Physics at Ludwig-Maximilians Uni­ver­­sity in Munich. In 2006, Ferenc Krausz became the spokesman of the Munich Centre for Advanced Photonics (MAP) Cluster of Excellence.

 

 

Thorsten_NaeserThorsten Naeser studied Physical Ge­­og­­­raphy at Ludwig-Maximilians University in Munich. After graduation he worked for five years as a freelance scientific journalist and photographer, focusing on topics related to natural sciences, med­­icine and archaeology. Since 2008, he has been working as a public relations officer at the MPI of Quantum Optics in Garching.